GPR214 polyclonal antibody

Product Description

GPR214 polyclonal antibody is available at gentaur for next week delivery

Background: Serine/threonine-protein phosphatase 4 regulatory subunit 2, regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.

Applications:  WB IHC

Purification&Purity: The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

Storage&Stability:  Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.

Specificity:  PPP4R2 polyclonal antibody detects endogenous levels of PPP4R2 protein.

W4BiowMW:  ~ 55 kDa

Reactivity: Human,Rat,Mouse

Note:  For research use only, not for use in diagnostic procedure.

Immunogen:

Synthetic peptide, corresponding to Human PPP4R2.

Alternative Name:

Serine/threonine-protein phosphatase 4 regulatory subunit 2; PPP4R2; SBBI57

Western blot analysis:  Western blot (WB) analysis of PPP4R2 polyclonal antibody at 1:500 dilution LaneA:CT-26 whole cell lysate LaneB:PC12 whole cell lysate LaneC:Hela whole cell lysate

Immunohistochemistry:

Immunofluorescence analysis:

Host:  Rabbit

Swiss-Prot: Q9NY27

 

 

 

 

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