Product Description
GPR206 polyclonal antibody is available at gentaur for next week delivery
Background: Phosphorylated adapter RNA export protein, a phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.
Applications: WB ICC
Purification&Purity: The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -25°C long term. Avoid freeze-thaw cycles.
Specificity: PHAX polyclonal antibody detects endogenous levels of PHAX protein.
W4BiowMW: ~ 55 kDa
Reactivity: Human,Rat,Mouse
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Synthetic peptide, corresponding to Human PHAX.Alternative Name:
Phosphorylated adapter RNA export protein; RNA U small nuclear RNA export adapter protein; PHAX; RNUXAWestern blot analysis: Western blot (WB) analysis of PHAX polyclonal antibody at 1:500 dilution LaneA:L02 whole cell lysate LaneB:MCF-7 whole cell lysate LaneC:SP2/0 whole cell lysate LaneD:H9C2 whole cell lysate
Immunohistochemistry:
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q9H814
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