Product Description
GPR124 polyclonal antibody is available at gentaur for next week delivery
Background: Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly. Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate.
Applications: WB IHC IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: GPR124 polyclonal antibody detects endogenous levels of GPR124 protein.
W4BiowMW: ~ 142 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Synthetic peptide, corresponding to Human GPR124.Alternative Name:
Adhesion G protein-coupled receptor A2; G-protein coupled receptor 124; Tumor endothelial marker 5; ADGRA2; GPR124; KIAA1531; TEM5Western blot analysis: Western blot (WB) analysis of GPR124 polyclonal antibody at 1:500 dilution LaneA:CT26 whole cell lysate LaneB:PMVEC whole cell lysate LaneC:MEF whole cell lysate LaneD:A549 whole cell lysate LaneE:LOVO whole cell lysate
Immunohistochemistry:
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q96PE1
"