Product Description
GLK polyclonal antibody is available at gentaur for next week delivery
Background: Several mammalian kinases have been identified which exhibit sequence similarity to the Saccharomyces cerevisiae serine/threonine kinase STE20. STE20 is involved in relaying signals from G-protein coupled receptors to cytosolic MAP kinase cascades, and it lies upstream of a MAP kinase kinase kinase. Mammalian STE20-like kinases include GLK, KHS, NIK, YSK1, HPK1, Krs-1, Krs-2 and human GC kinase. GLK (for GC-like kinase) is an 885 amino acid protein that shares a high degree of homology with GC kinase and HPK1. Like many of the STE20-like kinases, GLK specifically activates the JNK pathway. Epistasis studies with dominant negative mutants of MEKK1 suggest that GLK functions upstream of MEKK1 in the JNK signaling pathway.
Applications: WB IHC
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: GLK polyclonal antibody detects endogenous levels of GLK protein.
W4BiowMW: ~ 110kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human GLK.Alternative Name:
Mitogen-activated protein kinase kinase kinase kinase 3; MAPK/ERK kinase kinase kinase 3; MEK kinase kinase 3; Germinal center kinase related protein kinase; MEKKK 3; MAP4K3Western blot analysis: Western blot analysis of extracts of various cell lines, using MAP4K3 antibody.
Immunohistochemistry: Immunohistochemistry of paraffin-embedded human liver damage using MAP4K3 antibody.
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q8IVH8
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