Product Description
GJA3 polyclonal antibody is available at gentaur for next week delivery
Background: The connexin family of proteins form hexameric complexes called “connexons” that facilitate movement of low molecular weight proteins between cells via gap junctions. Connexin proteins share a common topology of four transmembrane α-helical domains, two extracellular loops, a cytoplasmic loop and cytoplasmic N- and C-termini. Many of the key functional differences arise from specific amino acid substitutions in the most highly conserved domains, the transmembrane and extracellular regions. Each of the approximately 20 connexin isoforms produces channels with distinct permeabilities and electrical and chemical sensitivities; therefore, one connexin usually cannot fully substitute for another. Consequently, a wide variety of malignant phenotypes associate with decreased connexin expression and gap junction communication, dependent on the particular connexin that is affected. For instance, deletion of the gene encoding connexin 46, normally expressed in the lens, produces severe cataracts.
Applications: WB
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: GJA3 polyclonal antibody detects endogenous levels of GJA3 protein.
W4BiowMW: ~ 53 kDa
Reactivity: Human
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
A synthetic peptide corresponding to residues in Human GJA3.Alternative Name:
Gap junction alpha-3 protein; Connexin-46; Cx46; GJA3Western blot analysis: Western blot (WB) analysis of GJA3 pAb at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:THP-1 whole cell lysate(40ug) Lane3:PC3 whole cell lysate(40ug)
Immunohistochemistry:
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q9Y6H8
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