Product Description
GITRL polyclonal antibody is available at gentaur for next week delivery
Background: GITRL (glucocorticoid-induced TNF-related ligand), a polypeptide encoded by a human umbilical endothelial cell cDNA, is a member of the TNF (tumor necrosis factor) superfamily. GITRL has a type 2 transmembrane topology that is characteristic of the TNF family. The TNF superfamilies regulate diverse biological functions, including cell proliferation, differentiation and survival. GITRL is found on vascular endothelial cells and in several peripheral tissues (small intestine, ovary, testis and kidney), where it may modulate T lymphocyte survival. The GITR receptor recognizes GITRL and the two interact to regulate NFκB activation. The ligand-receptor pair of GITRL-GITR protects cells against AICD (activation-induced cell death).
Applications: WB
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: GITRL polyclonal antibody detects endogenous levels of GITRL protein.
W4BiowMW: ~ 20 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Synthetic peptide, corresponding to Human GITRL.Alternative Name:
Tumor necrosis factor ligand superfamily member 18; Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRLWestern blot analysis: Western blot (WB) analysis of GITRL polyclonal antibody at 1:500 dilution LaneA:SK-OVCAR3 whole cell lysate LaneB:A2780 whole cell lysate LaneC:HEK293T whole cell lysate LaneD:The Testis tissue lysate of Mouse LaneE:The Testis tissue lysate of Rat
Immunohistochemistry:
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q9UNG2
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