Product Description
FSHR polyclonal antibody is available at gentaur for next week delivery
Background: Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G-protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its α and β subunits. While the α subunit of FSH is involved in the binding of FSH to the receptor, the β subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG). In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome; a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.
Applications: WB
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: FSHR polyclonal antibody detects endogenous levels of FSHR protein.
W4BiowMW: ~ 78 kDa
Reactivity: Human,Mouse
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human FSHR.Alternative Name:
Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor; LGR1Western blot analysis: Western blot analysis of extracts of various cell lines, using FSHR antibody at 1:1000 dilution. Lane1:SKOV3 whole cell lysate(40ug) Lane2:U-87MG whole cell lysate(40ug) Lane3:The Liver tissue lysate of Mouse(40ug) Lane4:The Liver tissue lysate of Rat(40ug) Exposure time: 20s.
Immunohistochemistry:
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: P23945
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