Product Description
FOSB (Phospho-S27) polyclonal antibody is available at gentaur for next week delivery
Background: Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the ‘leucine-zipper’ motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.
Applications: WB IHC IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: FOSB (Phospho-S27) polyclonal antibody detects endogenous levels of FOSB protein only when phosphorylated at Ser27.
W4BiowMW: ~ 36 kDa
Reactivity: Human,Mouse
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Synthetic phosphopeptide derived from human FOSB around the phosphorylation site of Serine 27.Alternative Name:
Protein fosB; G0/G1 switch regulatory protein 3; FOSB; G0S3Western blot analysis: Western blot (WB) analysis of FOSB (Phospho-S27) polyclonal antibody at 1:500 dilution LaneA:Hela whole cell lysate LaneB:U-87MG whole cell lysate LaneC:PC3 whole cell lysate
Immunohistochemistry:
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: P53539
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