FGFR2 (V501) polyclonal antibody

Product Description

FGFR2 (V501) polyclonal antibody is available at gentaur for next week delivery

Background: Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors.These include the Flg receptor or FGFR-1, the Bek receptor (or FGFR-2), FGFR-3, FGFR- 4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligandbinding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human Bek (also esignated K-sam) maps to chromosome 10q26 and is alternatively spliced to produce several isoforms. Heterogeneous mutations in Bek are associated with a range of craniosynostosis syndromes including Pfeiffer syndrome, Crouzon syndrome, Jackson-Weiss syndrome and Apert syndrome.

Applications:  WB IHC

Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability:  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity:  FGFR2 (V501) polyclonal antibody detects endogenous levels of FGFR2 protein.

W4BiowMW:  ~ 120,95,86 kDa

Reactivity: Human

Note:  For research use only, not for use in diagnostic procedure.

Immunogen:

Synthetic peptide, corresponding to amino acids 480-530 of Human FGFR2.

Alternative Name:

Fibroblast growth factor receptor 2; FGFR-2; K-sam; KGFR; Keratinocyte growth factor receptor; CD332; FGFR2; BEK; KGFR; KSAM

Western blot analysis:  Western blot (WB) analysis of FGFR2 pAb at 1:500 dilution Lane1:HepG2 whole cell lysate(40ug) Lane2:U-87MG whole cell lysate(40ug) Lane3:Myla2059 whole cell lysate(40ug) Lane4:HCT116 whole cell lysate (40ug)

Immunohistochemistry: Immunohistochemistry (IHC) analyzes of FGFR2 (V501) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Immunofluorescence analysis:

Host:  Rabbit

Swiss-Prot: P21802

 

 

 

 

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