Product Description
FEN1 polyclonal antibody is available at gentaur for next week delivery
Background: DNA replication, recombination and repair, all of which are necessary for genome stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. FEN-1 (for flap endonuclease) is an endonuclease that specifically cleaves the 5' flap structure of DNA in the process of DNA repair. FEN-1 is highly homologous to yeast Rad2. The C-terminal region of FEN-1 may bind to PCNA, thus allowing FEN-1 to function as an exonuclease in DNA replication.
Applications: WB IHC IF IP
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: FEN1 polyclonal antibody detects endogenous levels of FEN1 protein.
W4BiowMW: ~ 48 kDa
Reactivity: Human,Mouse
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human FEN1.Alternative Name:
Flap endonuclease 1; FEN-1; DNase IV; Flap structure-specific endonuclease 1; Maturation factor 1; MF1; hFEN-1; FEN1; RAD2Western blot analysis: WesternBlot (WB) analysis of FEN1 polyclonal antibody.
Immunohistochemistry: Immunohistochemistry (IHC) analysis of FEN1 pAb in paraffin-embedded Human Rectal Cancer tissue.
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: P39748
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