Product Description
Estrogen Receptor alpha polyclonal antibody is available at gentaur for next week delivery
Background: Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ERα and ERβ, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ERα and ERβ have been shown to be differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ERα and ERβ may be regulated by distinct mechanisms even though they share many functional characteristics
Applications: WB
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Estrogen Receptor alpha polyclonal antibody detects endogenous levels of Estrogen Receptor alpha protein.
W4BiowMW: ~ 66 kDa
Reactivity: Human,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Synthetic peptide, corresponding to Human Estrogen Receptor alpha.Alternative Name:
Estrogen receptor; ER-alpha; ER; ESR1; ESR; NR3A1Western blot analysis: Western blot (WB) analysis of Estrogen Receptor alpha polyclonal antibody at 1:500 dilution LaneA:HEK293T whole cell lysate LaneB:K562 whole cell lysate LaneC:The Liver tissue lysate of Rat
Immunohistochemistry:
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: P03372
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