Product Description
DSG1 polyclonal antibody is available at gentaur for next week delivery
Background: Desmogleins (dsgs) are type I membrane proteins that are important for cell adhesion and are expressed in great abundance at the desmosomes, which are adhesive cell junctions. The dsg proteins belong to the cadherin family and consist of dsg1, dsg2 and dsg3. Calcium binds to the putative calcium binding sites at the extracellular N-terminal domain of dsg1, which has cadherin-like repeats. Unlike normal human keratinocytes, the squamous cell carcinoma cells exhibit diminished or unusual expression of dsg3 and dsg1, which bear pemphigus vulgaris and pemphigus foliaceus antigens, respectively.
Applications: WB IHC IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: DSG1 polyclonal antibody detects endogenous levels of DSG1 protein.
W4BiowMW: ~ 150 kDa
Reactivity: Human,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant protein of human DSG1.Alternative Name:
Desmoglein-1; Desmoglein 1; Desmoglein1; Cadherin family member 4; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen; DSG1; CDHF4Western blot analysis: Western blot analysis of extracts of various cells, using DSG1 antibody.
Immunohistochemistry: Immunohistochemistry of paraffin-embedded human trachea using DSG1 antibody at dilution of 1:100 (x40 lens).
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q02413
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