Product Description
DOK7 polyclonal antibody is available at gentaur for next week delivery
Background: The downstream of kinase family (Dok1-7) are members of a class of “docking” proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Based on their similarities, the Dok family of proteins can be divided into three subgroups: Dok-1/2/3, Dok-4/5/6 and Dok-7. Through its interaction with musclespecific receptor kinase (MuSK), Dok-7 is crucial for neuromuscular synaptogenesis and for MuSK activation. Mice lacking Dok-7 do not form neuromuscular synapses nor acetylcholine receptor clusters. Mutations in the Dok-7 gene can cause congenital myasthenic syndromes (CMA)-recessively inherited disorders characterized by muscle weakness.
Applications: WB IHC IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: DOK7 polyclonal antibody detects endogenous levels of DOK7 protein.
W4BiowMW: ~ 53 kDa
Reactivity: Human,Mouse
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Synthetic peptide, corresponding to Human DOK7.Alternative Name:
Protein Dok-7; Downstream of tyrosine kinase 7; DOK7; C4orf25Western blot analysis: Western blot (WB) analysis of DOK7 polyclonal antibody at 1:500 dilution LaneA:HEK293T whole cell lysate LaneB:The Brain tissue lysate of Mouse LaneC:The Brain tissue lysate of Rat
Immunohistochemistry:
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q18PE1
"
