Product Description
DOCK11 polyclonal antibody is available at gentaur for next week delivery
Background: Small GTPases of the Rho family, Rho, Rac, and Cdc42, are critical regulators of the actin cytoskeleton and many other cellular processes. Rho GTPases are activated by Dbl-homology (DH)-domain-containing guanine nucleotide exchange factors (GEFs). DOCK 11 (dedicator of cytokinesis 11), also known as ACG or ZIZ2 (zizimin2), is a 2073 amino acid protein belonging to the DOCK family of cytokinesis-regulating proteins that is mainly expressed in peripheral blood leukocytes. DOCK 11 functions as a GEF that binds and activates Cdc42 by exchanging bound GDP for free GTP. Cdc42 mediates cell polarity, gene expression, cell cycle progression and cell–cell contacts. Similar to other DOCK family members, DOCK 11 contains a PH domain and two internal DOCK homology regions designated DHR1 and DHR2.
Applications: WB IHC
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: DOCK11 polyclonal antibody detects endogenous levels of DOCK11 protein.
W4BiowMW: ~ 230 kDa
Reactivity: Human,Rat,Mouse
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Synthetic peptide, corresponding to Human DOCK11.Alternative Name:
Dedicator of cytokinesis protein 11; Activated Cdc42-associated guanine nucleotide exchange factor; ACG; DOCK11Western blot analysis: Western blot (WB) analysis of DOCK11 polyclonal antibody at 1:2000 dilution Lane1:C6 whole cell lysate(40ug) Lane2:CT-26 whole cell lysate(40ug) Lane3:EC9706 whole cell lysate(40ug) Lane4:U-87MG whole cell lysate(40ug)
Immunohistochemistry: Immunohistochemistry of paraffin-embedded Human breast cancer using DOCK11 antibody at dilution of 1:50 (40x lens).
Immunofluorescence analysis: Immunohistochemistry of paraffin-embedded Human breast cancer using DOCK11 antibody at dilution of 1:50 (40x lens).
Host: Rabbit
Swiss-Prot: Q5JSL3
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