Product Description
CUL2 polyclonal antibody is available at gentaur for next week delivery
Background: CUL-1 mediated ubiquitination results in the degradation of cell cycle proteins cyclin D, p21 and cyclin E. Another cullin, CUL-3 facilitates the degradation of cyclin E independent of SCF activity, while CUL-2 associates with the tumor suppressing protein VHL and elongin B to form VBC complexes, which structurally resemble the SCF ligase. Proteolysis also occurs by way of CUL-4 associating with Nedd-8, a ubiquitin- like protein, where it too functions as an active component of a multifunctional E3 complex. CUL-5, or vasopressin-activated, calcium-mobilizing protein (VACM-1), is also included in the cullin family as it shares substantial sequence homology with CUL-1.
Applications: WB IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: CUL 2 polyclonal antibody detects endogenous levels of CUL 2 protein.
W4BiowMW: ~ 87 kDa
Reactivity: Human
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human CUL 2.Alternative Name:
Cullin 2; Cullin2; CUL2; CUL-2; CULLIN-2; MGC131970Western blot analysis: Western blot analysis of CUL 2 polyclonal antibody
Immunohistochemistry:
Immunofluorescence analysis: Immunofluorescence analysis of MCF7 cells, using CUL 2 polyclonal antibody
Host: Rabbit
Swiss-Prot: Q13617
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