Product Description
CTCF polyclonal antibody is available at gentaur for next week delivery
Background: CTCF belongs to the zinc finger transcription factor family, and it recognizes unusually long and remarkably divergent DNA target sequences to influence expression of many various genes. The DNA-binding domain of CTCF is composed of 11 Zn fingers including 10 that are of C2H2-class, and 1 that is of C2HC class, and they are highly conserved between vertebrate species. CTCF functions as a repressor of the c-myc gene and as a regulator of lysozyme gene expression. In addition, CTCF associates with the essential activator domain in the promotor region of the amyloid β-protein precursor (APP) gene to activate transcription of APP. Expression of CTCF up-regulates APP expression and thereby, enhances synapse formations between primary neurons during development.
Applications: WB IHC IF IP ChIP
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: CTCF polyclonal antibody detects endogenous levels of CTCF protein.
W4BiowMW: ~ 140 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human CTCF.Alternative Name:
11 zinc finger protein; 11 zinc finger transcriptional repressor; 11-zinc finger protein; CCCTC binding factor (zinc finger protein); CCCTC binding factor; CCCTC-binding factor; Ctcf; CTCF; CTCFL paralog; Transcriptional repressor CTCF;Western blot analysis: WesternBlot (WB) analysis of CTCF polyclonal antibody.
Immunohistochemistry: Immunohistochemistry of paraffin-embedded rat brain using CTCF antibody.
Immunofluorescence analysis: Immunoprecipitation analysis of 200ug extracts of HeLa cells, using 3 ug CTCF antibody.
Host: Rabbit
Swiss-Prot: P49711
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