CD31/PECAM-1 (T709) polyclonal antibody

Product Description

CD31/PECAM-1 (T709) polyclonal antibody is available at gentaur for next week delivery

Background: CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells and endothelial cells, and modulates cell adhesion, endothelial cell migration and angiogenesis. CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical stress or oxidative stress), presumably by Src family members. The tyrosine phosphorylation mediates associations with a number of SH2 domain containing binding partners such as PI3-kinase, SHIP, PLCγ and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules.

Applications:  WB IHC IF

Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability:  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity:  CD31/PECAM-1 (T709) polyclonal antibody detects endogenous levels of CD31 protein.

W4BiowMW:  ~ 140 kDa

Reactivity: Human,Mouse,Rat

Note:  For research use only, not for use in diagnostic procedure.

Immunogen:

Synthetic peptide, corresponding to amino acids 670-720 of Human CD31.

Alternative Name:

Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA'; PECA1; CD31; PECAM1

Western blot analysis:  Western blot (WB) analysis of CD31/PECAM-1 (T709) pAb at 1:500 dilution Lane1:A549 whole cell lysate(30ug) Lane2:Raw264.7 whole cell lysate(40ug) Lane3:C6 whole cell lysate(40ug)

Immunohistochemistry: Immunohistochemistry (IHC) analyzes of CD31/PECAM-1 (T709) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Immunofluorescence analysis:

Host:  Rabbit

Swiss-Prot: P16284

 

 

 

 

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