Caspase 12 (P99) polyclonal antibody

Product Description

Caspase 12 (P99) polyclonal antibody is available at gentaur for next week delivery

Background: Ced-3/caspase-1, is composed of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6 and caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9, caspase-10, caspase-14, and caspase-5/caspase-12. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-5 (also designated TY or ICErelIII) can cleave its own precursor, an activity that requires the cysteine 245 residue. The mouse homolog of caspase-5 is designated caspase-12. Frameshift mutations in caspase-5 have been identified in MMP tumors of the endometrium, colon and stomach, indicating that caspase-5 may be a new target gene in the microsatellite mutator pathway for cancer.

Applications:  WB IHC

Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability:  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity:  Caspase12 (P99) polyclonal antibody detects endogenous levels of Caspase12 protein.

W4BiowMW:  ~ 42 kDa

Reactivity: Human,Mouse,Rat

Note:  For research use only, not for use in diagnostic procedure.

Immunogen:

Synthetic peptide, corresponding to amino acids 65-123 of Human Caspase 12.

Alternative Name:

Inactive caspase-12; CASP-12; UNQ9415/PRO34398; CASP12; Caspase12

Western blot analysis:  Western blot analysis of extracts of various cell lines, using CASP12 Antibody.

Immunohistochemistry: Immunohistochemistry (IHC) analyzes of Caspase 12 (P99) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.

Immunofluorescence analysis:

Host:  Rabbit

Swiss-Prot: Q6UXS9

 

 

 

 

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