C4BPB polyclonal antibody

Product Description

C4BPB polyclonal antibody is available at gentaur for next week delivery

Background: Complement component 4-binding protein (C4BP) is a plasma glycoprotein that inhibits the classical pathway of complement activation, which is mediated through antibody targeting of foreign antigen. Structurally, C4BP is a disulfide linked, multimeric protein that is composed of seven α chains and one β chain. C4BP functions as a cofactor for C3β inactivator in the cleavage of C3β, and accelerates the decay of C4βC2α (C3 convertase) by acting as a cofactor in the cleavage of C4β by factor I. Streptococcal strains that express Ig-binding cell surface molecules, which are members of the M protein family,can bind to overlapping C4β binding sites in C4BP and therefore, interfere with the classical pathway of complement activation. Bacteria-bound C4BP may be an evolved mechanism that downregulates complement activation in the bacterial host microenvironment, thereby reducing the occurances of bacterial opsonization and phagocytosis.

Applications:  WB IHC IF

Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability:  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity:  C4BPB polyclonal antibody detects endogenous levels of C4BPB protein.

W4BiowMW:  ~ 54 kDa

Reactivity: Human,Mouse,Rat

Note:  For research use only, not for use in diagnostic procedure.

Immunogen:

Alternative Name:

Western blot analysis:  Western blot analysis of extracts of various cells, using C4BPB antibody.

Immunohistochemistry: Immunohistochemistry of paraffin-embedded human stomach using C4BPB antibody at dilution of 1:100 (40x lens).

Immunofluorescence analysis: Immunohistochemistry of paraffin-embedded mouse kidney using C4BPB antibody at dilution of 1:100 (40x lens).

Host:  Rabbit