Product Description
BRCA1 polyclonal antibody is available at gentaur for next week delivery
Background: BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. It combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
Applications: WB IHC IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: BRCA1 polyclonal antibody detects endogenous levels of BRCA1 protein.
W4BiowMW: ~ 85 kDa
Reactivity: Human,Mouse
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human BRCA1.Alternative Name:
Breast cancer type 1 susceptibility protein; RING finger protein 53; BRCA1; RNF53Western blot analysis: WesternBlot (WB) analysis of BRCA1 polyclonal antibody.
Immunohistochemistry: Immunohistochemistry (IHC) analysis of BRCA1 pAb in paraffin-embedded Human Esophageal Cancer tissue.
Immunofluorescence analysis: Immunofluorescence analysis of A549 cells, using BRCA1 polyclonal antibody
Host: Rabbit
Swiss-Prot: P38398
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