Product Description
Beclin 1 polyclonal antibody is available at gentaur for next week delivery
Background: BECN1 (beclin 1) is a coiled-coil protein that has been implicated as an inhibitor of tumorigenesis. BECN1, which associates with Bcl-2, plays a significant role in autophagy. Autophagy is the degradation of cellular proteins in the lysosomes, and when this pathway is suppressed, cell growth is deregulated. Autophagy is controlled by the same signal transduction pathway that induces the phosphorylation of the ribosomal protein S6, and both are mediated via amino acids. BECN1 expression in various carcinoma cell lines, such as MCF7, is low, whereas it is ubiquitously expressed in normal breast tissue.
Applications: WB IHC IF IP
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Beclin 1 polyclonal antibody detects endogenous levels of Beclin 1 protein.
W4BiowMW: ~ 60 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human Beclin 1.Alternative Name:
APG6; ATG 6; ATG6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein beclin; Beclin 1 (coiled coil moesin like BCL2 interacting protein); Beclin 1 autophagy related; Beclin-1; Beclin1; BECN 1; BECN1; BECN1; Coiled coil myosin like BCL2 interacting protein; Coiled-coil myosin-like BCL2-interacting protein; GT197; Protein GT197 antibodWestern blot analysis: Western blot analysis of extracts of various cell lines, using Beclin 1 antibody.
Immunohistochemistry: Immunohistochemistry of paraffin-embedded human breast cancer using Beclin 1 antibody at dilution of 1:100 (40x lens).
Immunofluorescence analysis: Immunofluorescence analysis of HeLa cells using Beclin 1 antibody at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Host: Rabbit
Swiss-Prot: Q14457
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