BCCIP polyclonal antibody

Product Description

BCCIP polyclonal antibody is available at gentaur for next week delivery

Background: This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene.

Applications:  WB IHC

Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability:  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity:  BCCIP polyclonal antibody detects endogenous levels of BCCIP protein.

W4BiowMW:  ~ 50 kDa

Reactivity: Human,Mouse,Rat

Note:  For research use only, not for use in diagnostic procedure.

Immunogen:

Alternative Name:

Western blot analysis:  Western blot analysis of extracts of various cells, using BCCIP antibody.

Immunohistochemistry: Immunohistochemistry of paraffin-embedded human gastric cancer using BCCIP antibody at dilution of 1:100 (x40 lens).

Immunofluorescence analysis: Immunohistochemistry of paraffin-embedded human lung cancer using BCCIP antibody at dilution of 1:100 (x40 lens).

Host:  Rabbit