Product Description
AXL polyclonal antibody is available at gentaur for next week delivery
Background: Axl, Sky, and Mer are three members of a receptor tyrosine kinase (RTK) family that share a conserved intracellular tyrosine kinase domain and an extracellular domain similar to those seen in cell adhesion molecules. These RTKs bind the vitamin K-dependent protein growth-arrest-specific 6 (Gas6), which is structurally related to the protein S anticoagulation factor. Upon binding to its receptor, Gas6 activates phosphatidylinositol 3-kinase (PI3K) and its downstream targets Akt and S6K, as well as NF-κB. A large body of evidence supports a role for Gas6/Axl signaling in cell growth and survival in normal and cancer cells.
Applications: WB
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: AXL polyclonal antibody detects endogenous levels of AXL protein.
W4BiowMW: ~ 115kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Synthetic peptide, corresponding to Human AXL.Alternative Name:
Tyrosine-protein kinase receptor UFO; AXL oncogene; AXL; UFOWestern blot analysis: Western blot (WB) analysis of AXL polyclonal antibody at 1:500 dilution Lane1:PC3 whole cell lysate(40ug) Lane2:HEK293T whole cell lysate(40ug) Lane3:U-87MG whole cell lysate(40ug) Lane4:SK-OVCAR3 whole cell lysate(40ug) Lane5:C6 whole cell lysate(40ug) Lane6:CT-26 whole cell lysate(40ug)
Immunohistochemistry:
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: P30530
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