Product Description
ATXN3 polyclonal antibody is available at gentaur for next week delivery
Background: Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins. Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. In response to misfolded substrate ubiquitination, mediates deubiquitination of monoubiquitinated STUB1/CHIP.
Applications: WB IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: ATXN3 polyclonal antibody detects endogenous levels of ATXN3 protein.
W4BiowMW: ~ 50 kDa
Reactivity: Human,Mouse
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Recombinant full length Human ATXN3.Alternative Name:
Ataxin-3; Machado-Joseph disease protein 1; Spinocerebellar ataxia type 3 protein; ATXN3; ATX3; MJD; MJD1; SCA3Western blot analysis: WesternBlot (WB) analysis of ATXN3 polyclonal antibody.
Immunohistochemistry:
Immunofluorescence analysis: Immunofluorescence analysis of Hela cells, using ATXN3 polyclonal antibody
Host: Rabbit
Swiss-Prot: P54252
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