Product Description
Ataxin 1 (Phospho-S775) polyclonal antibody is available at gentaur for next week delivery
Background: Ataxin-1, also designated spinocerebellar ataxia type 1 protein (Sca-1), is differentially expressed and localizes to both the cytoplasm and the nucleus. Mutations in Ataxin-1 are associated with the onset of the autosomal dominant neurodegenerative disorder spinocerebellar ataxia type 1 (SCA-1), which is characterized by progressive neuronal loss in the cerebellum, muscle wasting and ataxia. In Purkinje cells, where SCA-1 is predominantly observed, Ataxin-1 has been shown to directly associate with the Purkinje-enriched leucine-rich acidic nuclear protein (LANP) and the nuclear matrix-associated protein promyelocytic leukemia protein PML. In SCA-1, Ataxin-1 is mutated to encode a polyglutamine protein that forms nuclear aggregates, which interact significantly more strongly with LANP and contribute to the pathogenesis of SCA-1.
Applications: WB IHC IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Ataxin 1 (Phospho-S775) polyclonal antibody detects endogenous levels of Ataxin 1 protein only when phosphorylated at Ser775.
W4BiowMW: ~ 105 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Synthetic phosphopeptide derived from human Ataxin 1 around the phosphorylation site of Serine 775.Alternative Name:
alternative ataxin1; Ataxin-1; ATX1; ATX1_HUMAN; Atxn1; D6S504E; SCA1; Spinocerebellar ataxia type 1 proteinWestern blot analysis: Western blot (WB) analysis of Ataxin 1 (Phospho-S775) polyclonal antibody at 1:500 dilution LaneA:HGC27 whole cell lysate LaneB:The Lung tissue lysate of Mouse
Immunohistochemistry:
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: P54253
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