Product Description
Arrestin-β-1 (E406) polyclonal antibody is available at gentaur for next week delivery
Background: Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane.
Applications: IHC IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Arrestin-β-1 (E406) polyclonal antibody detects endogenous levels of Arrestin-β-1 protein.
W4BiowMW: ~ 51 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Synthetic peptide, corresponding to amino acids 390-440 of Human Arrestin-β-1.Alternative Name:
ARB 1; ARB1; ARR 1; ARR1; ARRB 1; ARRB1; Arrestin 2; Arrestin beta 1; Arrestin beta-1; Beta-arrestin-1; Arrestin-β1; Arrestin β1; β-arrestin-1Western blot analysis: Western blot (WB) analysis of ARRB1 pAb at 1:2000 dilution Lane1:A549 whole cell lysate(40ug) Lane2:The Brain tissue lysate of Mouse(30ug) Lane3:The Brain tissue lysate of Rat(40ug) Lane4:Panc1 whole cell lysate(40ug) Lane5:HEK293T whole cell lysate(40ug) Lane6:C6 whole cell lysate(40ug)
Immunohistochemistry: Immunohistochemistry (IHC) analyzes of Arrestin-β-1 (E406) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: P49407
"
