APP/β-Amyloid polyclonal antibody

Product Description

APP/β-Amyloid polyclonal antibody is available at gentaur for next week delivery

Background: Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the β-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer’s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the Amyloid β/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer’s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP. Human APLP2 is a membrane- bound sperm protein that contains a region highly homologous to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer’s disease patients.

Applications:  WB IHC

Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability:  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity:  APP/β-Amyloid polyclonal antibody detects endogenous levels of Amyloid beta A4 protein.This antibody does not cross-react with other β-amyloid peptides.

W4BiowMW:  ~ 110 kDa

Reactivity: Human,Mouse,Rat

Note:  For research use only, not for use in diagnostic procedure.

Immunogen:

Recombinant full length Human APP/β-Amyloid.

Alternative Name:

Amyloid beta A4 protein; ABPP; APPI; Short name=APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; Short name=CVAP; PreA4; Protease nexin-II; Short name=PN-II; N-APP; Soluble APP-alpha; Short name=S-APP-alpha; Soluble APP-beta; Short name=S-APP-beta; Beta-amyloid protein 42; Beta-APP42; Beta-amyloid protein 40; Beta-APP40; P3(42); P3(40); Gamma-secretase C-terminal fragment 59; Amyloid intracellular domain 59; Short name=AICD-59; Short name=AID(59); Gamma-CTF(59); Gamma-secretase C-terminal fragment 57; Amyloid intracellular domain 57; Short name=AICD-57; Short name=AID(57); Gamma-CTF(57); Gamma-secretase C-terminal fragment 50; Amyloid intracellular domain 50; AICD-50; AID(50); Gamma-CTF(50); APP; A4; AD; Amyloid-β; Amyloid β; Amyloidβ; β Amyloid; βAmyloid; Aβ

Western blot analysis:  WesternBlot (WB) analysis of β-Amyloid polyclonal antibody.

Immunohistochemistry: Immunohistochemistry (IHC) analysis of β-Amyloid pAb in paraffin-embedded Human Stomach Cancer tissue.

Immunofluorescence analysis:

Host:  Rabbit

Swiss-Prot: P05067

 

 

 

 

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