Anti-Chymotrypsin

Alpha-1-Anti-Chymotrypsin Antibodies (see rabbit polyclonal and mouse monolconals below)

Rabbit anti-Alpha-1-anti-chymotrypsin

cat# RDI-A1ACTabr  $281.00/1ml

Presentation: 1ml purified rabbit antibody fraction in 10mM PBS, pH 7.4, with 0.2% BSA and 15mM sodium azize

Immunogen: Purified human serum Alpha-1-Antichymotrypsin

Species Reactivity: Human. Does not react with cow, horse, goat, sheep, pig, mink, kangaroo, cat,dog, guinea pig, mouse, rat, chicken

Known Applications: Immunohistology (frozen & formalin/paraffin) (For staining of formalin-fixed, paraffin-embedded tissues, digest the sections with trypsin at 1mg/ml PBS, for 5 min at RT).

Positive Control: Monocytes and macrophages in colon, tonsil, or skin

Cellular Localization: Cytoplasmic

Working Dilutions: Immunohistology: 1:50-1:100 (30 minute at RT) The optimal dilution for a specific application under a given set of experimental conditions should be determined by the investigator.

Storage : Store vial at 2-8 DEG C.

Specificity : Recognizes a protein of 62kDa which is identified as Alpha-1-Antichymotrypsin (Alpha-1-ACT). This polyclonal antibody is highly specific to Alpha-1-ACT and shows no cross-reaction with other related proteins. Alpha 1-ACT is an early-stage acute-phase plasma protein and a serpin that preferentially inactivates chymotrypsin, cathepsin G, and chymase. Alpha-1-ACT, a serine protease inhibitor, is tightly associated with amyloid plaques in Alzheimer's disease (AD) and in normal aged human and monkey brain. Regulation of the serine proteases and serine protease inhibitors plays an important role in neuromuscular differentiation. Prostate specific antigen (PSA), a chymotrypsin-like serine protease, is predominantly complexed to Alpha-1-ACT. A higher proportion of serum PSA is complexed to Alpha-1- ACT in prostate cancer than in benign prostate hyperplasia.

For Research Use Only

-also available mouse anti-alpha-1-antichymotrypsin

4 clones sample pack cat#RDI-A1ACTabm-PK $438.00 (4 X 0.25mg) individual clones $438.00/1mg Bulk on request