Anti-Acetyl CoA Carboxylase 1(ACC1) polyclonal antibody

Product Description

Anti-Acetyl CoA Carboxylase 1(ACC1) polyclonal antibody is available at gentaur for next week delivery

Background: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACCα (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCβ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACCα is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzyme’s short-term regulatory mechanism. The gene encoding ACCα maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACCβ is homologous to that of the ACCα, except for an additional peptide of about 150 amino acids at the N-terminus.

Applications:  WB IHC

Purification&Purity: ProA affinity purified

Storage&Stability:  Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity:  ACC1 polyclonal antibody detects endogenous levels of ACC1 protein.

W4BiowMW:  ~ 265 kDa

Reactivity: Human, Mouse, Rat

Note:  For research use only, not for use in diagnostic procedure.

Immunogen:

recombinant protein

Alternative Name:

ACACB, ACC2, ACCB, ACAC, ACACA, ACACA, ACACB, ACC alpha, ACC, ACC beta, ACC-alpha, ACC1, ACC2, ACCA, ACCB, Acetyl CoA carboxylase 1, Acetyl CoA carboxylase 2, Acetyl CoA carboxylase alpha, Acetyl CoA carboxylase beta, Acetyl Coenzyme A carboxylase alpha, Acetyl Coenzyme A carboxylase beta, Biotin carboxylase, COA1, COA2, HACC275, OTTHUMP00000164069, OTTHUMP00000164070, OTTHUMP00000164076, OTTHUMP00000240532,

Western blot analysis:  Western blot analysis of Acetyl CoA Carboxylase 1 on mouse kidney lysates using anti-Acetyl CoA Carboxylase 1 antibody at 1/1,000 dilution.

Immunohistochemistry: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Acetyl CoA Carboxylase 1 antibody. Counter stained with hematoxylin.

Immunofluorescence analysis:

Host:  Rabbit

Swiss-Prot: Q13085

 

 

 

 

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