Product Description
ADAM17 polyclonal antibody is available at gentaur for next week delivery
Background: Tumor necrosis factor β (TNFβ), also known as lymphotoxin, is a pleiotropic cytokine. TNFα, also known as cachetin, is a cytokine that binds to the same receptors, producing an array of effects similar to those of TNFβ. TNFβ and TNFα share 30% amino acid homology and have similar biological activities. TNFβ is produced by activated lymphocytes, including CD4+ T helper cell type 1 lymphocytes, CD8+ lymphocytes and certain B lymphoblastoid cell lines. TNFα is produced by several different cell types, including lymphocytes, neutrophils and macrophages. TNFβ and TNFα can modulate many immune and inflammatory functions while having the ability to inhibit tumor growth. TACE (for TNFα converting enzyme) is a metalloproteinase that cleaves the membrane-bound TNFα precursor to release soluble TNFα.
Applications: WB IHC IF
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: ADAM17 polyclonal antibody detects endogenous levels of ADAM17 protein.
W4BiowMW: ~ 115 kDa
Reactivity: Human,Mouse,Rat
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
A synthetic peptide of human ADAM17.Alternative Name:
CSVP; TACE; NISBD; ADAM18; CD156B; NISBD1;Western blot analysis: Western blot analysis of extracts of various cell lines, using ADAM17 antibody.
Immunohistochemistry: Immunohistochemistry of paraffin-embedded rat heart using ADAM17 antibody at dilution of 1:100 (40x lens).
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: P78536
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