Product Description
ABHD14B polyclonal antibody is available at gentaur for next week delivery
Background: The α/β hydrolase superfamily comprise diverse members that are involved in important biochemical processes and related to various diseases. They have unrelated sequences, various substrates, and different kinds of catalytic activities, yet they share the same canonical α/β hydrolase fold, which consists of an eightstranded parallel α/β structure. They are also characterized by a catalytic triad composed of a histidine, an acid and a nucleophile. Members of this superfamily are often drug targets for treating diseases, such as diabetes, Alzheimer’s disease, obesity and blood clotting disorders. The Ab hydrolase domain containing (ABHD) gene subfamily is comprised of 15 mostly uncharacterized members. Most of which utilize a serine nucleophile to form the G-X-S-X-G nucleophile elbow. ABHD1 plays a role in metabolizing smoking xenobiotics. ABHD2 participates in the development of atherosclerosis. ABHD4 is involved in an alternative synthesis pathway of NAE. Mutations in ABHD5 contribute to Chanarin-Dorfman syndrome. ABDH6 may play a role in nervous system metabolism and signaling. ABHD14B is a 210 amino acid protein that localizes to both the cytoplasm and the nucleus where it exists as 2 alternatively spliced isoforms.
Applications: WB
Purification&Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: ABHD14B polyclonal antibody detects endogenous levels of ABHD14B protein.
W4BiowMW: ~ 22 kDa
Reactivity: Human,Rat,Mouse
Note: For research use only, not for use in diagnostic procedure.
Immunogen:
Synthetic peptide, corresponding to Human ABHD14B.Alternative Name:
Protein ABHD14B; Alpha/beta hydrolase domain-containing protein 14B; Abhydrolase domain-containing protein 14B; CCG1-interacting factor B; ABHD14B; CIBWestern blot analysis: Western blot (WB) analysis of ABHD14B polyclonal antibody at 1:500 dilution Lane1:The Spleen tissue lysate of Mouse(20ug) Lane2:The Thymus tissue lysate of Rat(20ug) Lane3:Jurkat whole cell lysate(40ug) Lane4:K562 whole cell lysate(40ug) Lane5:HEK293T whole cell lysate(40ug)
Immunohistochemistry:
Immunofluorescence analysis:
Host: Rabbit
Swiss-Prot: Q96IU4
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