rev: June 6, 2003
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(anti-Human and others as indicated)
RDI Division of Fitzgerald Industries Intl offers a wide line of antibodies. Since no one antibody works best for all applications (neutralization, blotting, histochemistry, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.
dystrophic neurites surronding a senile plaque
that are histochemically stained
Background: The amyloid precursor protein (APP) is a large membrane protein whose N terminus projects into the extracellular space. In Alzheimer's disease, this protein is broken down and releases the 42 amino acid B-amyloid protein that is found in senile plaques and vessels
Price: $315.00/0.25ml $1125.00/ml 1 or more Bulk on request
Package Size: neat serum
Antigen: synthetic peptide corresponding to amino acids 44-63 of the N terminus of the human Alzheimer's Amyloid Precursor Protein (APP)
sequence: H M N V Q N G K W D D D P S G T K T C I
(control peptide available: cat#RDI-AMYPRE-CPX $470.00/1mg)
Specificity: specific for residues 44-63 on the N- terminus of APP
Optimal titers must be determined empirically by each end user.
USE: Elisa using immunizing peptide 1:1500
histochemistry (pfa fixed frozen) 1:5K
formalin fixed paraffin 1:100
(shows immunoreactivity with APP containing neurons and will label dystrophic neurites in senile plaques).
ref: Biochem Biophy Res Comm 156:432-437, 1988.
Storage: Store 4 DEG c (short term) or -20 DEG C long term. Recommend aliquot and store at -20 DEG C . Avoid frequent freeze thaw cycles.
Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.
34 Junction Square Drive
Concord MA 01742-3049
phone (978) 371-6446 or (800) 370-2222
fax (978) 371-2266
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