rev:       September 6, 2004

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  ANTIBODIES  

(anti-Human and others as indicated)

RDI Division of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.


Kallikrein (see 8 antibodies below)
Anti-Hippostatin/KLK11 Polyclonal Antibody

Catalog Number: RDI-ALS24312      $312.00/100ug

                            RDI-ALS24312X   $1875.00/1mg

Lot Number:

Quantity: 100ug in 100 ul (1 mg/ml) in PBS containing 0.02% sodium azide.

Description: Hippostasin, also known as KLK11, is a kallikrein-like serine protease, which has two alternatively spliced isoforms, brain-type and prostate-type. Hippostasin plays a role in the prostate, including reproductive and/or tumorigenic functions. Elevated serum levels of hK11 were found in 70% of women with ovarian cancer and in 60% of men with prostate cancer. Analysis of the KLK11 biomarker in serum may aid in the diagnosis and monitoring of ovarian and prostatic carcinoma.

Host Species: Rabbit

Specificity: Reacts with residues 68-82 [YIVHLGQHNLQKEEG] of the 35 kDa human hippostasin/KLK11protein. Cross reactivity to mouse and rat: 86% sequence identity.

Applications: Western blot - Use at 1:500-1,000 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Format: Affinity purified IgG

Storage: Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.

References: Diamandis,E.P. et al. Cancer Res. 62 (1), 295-300 (2002).

                    Nakamura,T et al. Prostate. 54(4), 299-305 (2003).

For in vitro research use only; not for use in or on humans or animals-not for use in diagnostics


Anti-KLK14 Polyclonal Antibody

Catalog Number: RDI-ALS24240      $312.00/vial 100ug

                            RDI-ALS24240X   $1875.00/1mg

Lot Number:

Quantity: 100 ug in 100ul (1 mg/ml) in PBS containing 0.02% sodium azide.

Description: Kallikreins are a subgroup of serine proteases and are implicated in carcinogenesis. The novel KLK gene, KLK14 is expressed by both benign and malignant glandular epithelial cells, thus exhibiting an expression pattern similar to that of two other prostatic kallikreins, KLK2 and KLK3.

Host Species: Rabbit

Specificity: Reacts with residues 239-251 [KYRSWIEETMRDK] of the human KLK14 protein.

Applications: Western blot - Use at 1:500 to 1:1,000 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Format: Affinity purified IgG

Storage: Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.

Reference: Hooper JD, Bui LT, Rae FK, Harvey TJ, Myers SA, Ashworth LK, and Clements JA. Genomics 2001 Apr 1;73(1):117-22.

For research use only; not for use in or on humans or animals-not for use in diagnostics


Anti-KLK-L1 Polyclonal Antibody

Catalog Number: RDI-ALS24234      $312.00/100ug

                            RDI-ALS24234X   $1875.00/1Mg

Lot Number:

Quantity: 100ug in 100ul (1 mg/ml) in PBS containing 0.02% sodium azide.

Description: Kallikreins are a subgroup of serine proteases and are implicated in carcinogenesis. A novel Kallikrein gene Prostase/KLK-L1 (also known as KLK4) is expressed and is up-regulated by androgens and progestins. KLK-L1 may be involved in the pathogenesis and/or progression of prostate, breast, and possibly other malignancies.

.Host Species: Rabbit

Specificity: Reacts with residues 242-254 [KFTEWIEKTVQAS] of the human 39 kDa KLK-L1 protein.

Applications: Western blot - Use at 1:500 to 1:1,000 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Format: Affinity purified IgG

Storage: Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.

Reference: Stephenson SA, Verity K, Ashworth LK, and Clements JA. J Biol Chem 1999 Aug 13;274(33):23210-4

For research use only; not for use in or on humans or animals-not for use in diagnostics


Anti-KLK-3 (Prostate Specific Antigen) Polyclonal Antibody

Catalog Number: RDI-ALS24235       $312.00/100ug

                            RDI-ALS24235X   $1875.00/1mg

Lot Number:

Quantity: 100ug in 100ul (1 mg/ml) in PBS containing 0.02% sodium azide.

Description: Kallikreins are a subgroup of serine proteases and are implicated in carcinogenesis. KLK 3 (also known as prostate specific antigen) is a marker for prostatic cancer and is involved in the pathogenesis and/or progression of prostate, breast, and possibly other malignancies.

Host Species: Rabbit

Specificity: Reacts with residues 247-261 [VHYRKWIKDTIVANP] of the human KLK3 protein.

Applications: Western blot - Use at 1:500 to 1:1,000 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Format: Affinity purified IgG

Storage: Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.

Reference: Henttu P, and Vihko P. Biochem Biophys Res Commun 1989 Apr 28;160(2):903-10.

For research use only; not for use in or on humans or animals-not for use in diagnostics

see also monoclonals to PSA and PSA antigen


Anti-KLK-L3 (KLK9) Polyclonal Antibody

Catalog Number: RDI-ALS24236       $312.00/100ug

                            RDI-ALS24236X    $1875.00/1mg

Lot Number:

Quantity: 100ug in 100ul (1 mg/ml) in PBS containing 0.02% sodium azide.

Description: Kallikreins are a subgroup of serine proteases and are implicated in carcinogenesis. (KLK-L3; HGMW-approved symbol KLK9) is a novel kallikrein gene with utility for diagnosis, monitoring and therapeutics of various cancers including those of the breast, prostate and testis.

Host Species: Rabbit

Specificity: Reacts with residues 239-250 [HYLDWIQEIMEN] of the human KLK-L3 (KLK9) protein.

Applications: Western blot - Use at 1:500 to 1:1,000 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Format: Affinity purified IgG

Storage: Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.

Reference: Yousef GM, and Diamandis EP. Genomics 2000 Apr 15;65(2):184-94.


Anti-KLK12 Polyclonal Antibody

Catalog Number: RDI-ALS24237      $312.00/100ug

                            RDI-ALS24237X   $1875.00/1mg

Lot Number:

Quantity: 100ug in 100ul (1 mg/ml) in PBS containing 0.02% sodium azide.

Description: Kallikreins are a subgroup of serine proteases and are implicated in carcinogenesis. A novel KLK gene, KLK12, is expressed in a variety of tissues including salivary gland, stomach, uterus, lung, thymus, prostate, colon, brain, breast, thyroid, and trachea. It has applications as a novel cancer biomarker.

Host Species: Rabbit

Specificity: Reacts with residues 236-248 [KYVDWIRMIMRNN] of the human KLK12 protein.

Applications: Western blot - Use at 1:500 to 1:1,000 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Format: Affinity purified IgG

Storage: Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.

Reference: Yousef GM, Magklara A, and Diamandis EP. Genomics 2000 Nov 1;69(3):331-41

For research use only; not for use in or on humans or animals-not for use in diagnostics


Anti-KLK-L2 (KLK5) Polyclonal Antibody

Catalog Number: RDI-ALS24238       $312.00/100ug

                            RDI-ALS24238X    $1875.00/1mg

Lot Number:

Quantity: 100ug in 100ul (1 mg/ml) in PBS containing 0.02% sodium azide.

Description: Kallikreins are a subgroup of serine proteases and are implicated in carcinogenesis. The novel KLK gene, KLK-L2 (also known as KLK5) is expressed in breast, brain, and testis and is up-regulated by estrogens and progestins

Host Species: Rabbit

Specificity: Reacts with residues 280-293 [KFTKWIQETIQANS] of the human KLK-L2 protein.

Applications: Western blot - Use at 1:500 to 1:1,000 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Format: Affinity purified IgG

Storage: Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.

Reference: Yousef GM, and Diamandis EP. J Biol Chem 1999 Dec 31;274(53):37511-6.

For research use only; not for use in or on humans or animals-not for use in diagnostics


Anti-KLK-L4 Polyclonal Antibody

Catalog Number: RDI-ALS24239     $312.00/100ug

                            RDI-ALS24239X   $1875.00/1mg

Lot Number:

Quantity: 100ug in 100ul(1 mg/ml) in PBS containing 0.02% sodium azide.

Description: Kallikreins are a subgroup of serine proteases and are implicated in carcinogenesis. The novel KLK gene, KLK-L4, is expressed in a variety of tissues including prostate, salivary gland, breast, and testis. Its expression is regulated by steroid hormones in breast cancer cell lines may be involved in the pathogenesis and/or progression of breast cancer.

Host Species: Rabbit

Specificity: Reacts with residues 262-277 [IRKYETQQQKWLKGPQ] of the human KLK-L4 protein.

Applications: Western blot - Use at 1:500 to 1:1,000 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

Format: Affinity purified IgG

Storage: Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.

Reference: Yousef GM, Chang A, Diamandis EP. J Biol Chem 2000 Apr 21;275(16):11891-8.

For research use only; not for use in or on humans or animals-not for use in diagnostics


RDI Division of Fitzgerald Industries Intl

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com

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