rev:   September 21, 2004

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  ANTIBODIES  

(anti-Human and others as indicated)

RDI Division of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.


BCL-XL / BCL-Xs antibodies (monoclonal and polyclonal)
Mouse anti-BCL-Xl Monoclonal ab  Rat/Mouse/Chick

cat# RDI-BCLXLabm     $438.00/vial 50ug (0.2ml)

        RDI-BCLXLabm-1   $750.00/vial 150ug (0.6ml)


Background: BCL-x is related to the BCL-2 protein and can function independently of BCL-2 in regulating apoptosis. the bcl-x transcript is expressed in a number of tissues, with the highest levels seen in the lymphoid and central nervous systems. Two distinct cDNA species, bcl-xl and bcl-xs, have been observed and appear to arise from alternate 5' splice sites located within the first coding exon of bcl-x gene. BCL-xl is composed of 233 amino acids and is similar in size and structure to bcl-2. The bcl-xs polypeptide shows a deletion of 63 amino acids which consist of the region of bcl-xl with the highest degree of amino acid identity to bcl-2. Like bcl-2, bcl-xl is capable of inhibiting cell death upon growth factor withdrawal when it is transfected into an IL-3 dependent cell line. However, the bcl-xs gene product inhibits the ability of bcl-2 to enhance cell survival in the absence of growth factors.


isotype: mIgG2b


package: 50ug or 150ug purified IgG1 at 0.25mg/ml in 50% glycerol, 20mM sodium phosphate pH 7.5, 150mM NaCl, 1.5mM NaN3, 1mg/ml BSA

antigen: a fragment corresponding to amino acids 18-233 of rat bcl-Xl protein


USe: Suitable for western blot on rat, mouse and chick using approx 0.5-1.0 ug/ml ab on total cell lysate of mouse macrophages. Major band at Mw 26kDa. -immunohistochemistry & immunofluorescence (also on rabbit brain).


Storage: Store at -20 DEG C upon receipt. Avoid frequent freeze thaw cycles. Recommend aliquoting. Avoid frequent freeze thaw cycles.


Main REF: Boise, L.H. et al, 1993 CELL 74:5976


Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.


copyright by owner


RABBIT anti-BCL-Xl  POLYCLONAL ab

cat# RDI-BCLXLabR     $438.00/vial 50ug (0.2ml)

       RDI-BCLXLabR-1    $750.00/vial 150ug (0.6ml)

Background: BCL-x is related to the BCL-2 protein and can function independently of BCL-2 in regulating apoptosis. the bcl-x transcript is expressed in a number of tissues, with the highest levels seen in the lymphoid and central nervous systems. Two distinct cDNA species, bcl-xl and bcl-xs, have been observed and appear to arise from alternate 5' splice sites located within the first coding exon of bcl-x gene. BCL-xl is composed of 233 amino acids and is similar in size and structure to bcl-2. The bcl-xs polypeptide shows a deletion of 63 amino acids which consist of the region of bcl-xl with the highest degree of amino acid identity to bcl-2. Like bcl-2, bcl-xl is capable of inhibiting cell death upon growth factor withdrawal when it is transfected into an IL-3 dependent cell line. However, the bcl-xs gene product inhibits the ability of bcl-2 to enhance cell survival in the absence of growth factors.


isotype: rabbit IgG


package: 50ug or 150ug purified IgG1 at 0.25mg/ml in 50% glycerol, 20mM sodium phosphate pH 7.5, 150mM NaCl, 1.5mM NaN3, 1mg/ml BSA


antigen: a fragment corresponding to amino acids   18-233 of rat bcl-Xl protein

USe: Suitable for western blot on human, rat, mouse, dog and chicken using approx 0.5-0.25 ug/ml ab on total cell lysate of human endothelial lysate. Major band at Mw 26kDa. -immunofluorescence (also on A431 cells & mouse cerebrum).


Storage: Store at -20 DEG C upon receipt. Avoid frequent freeze thaw cycles. Recommend aliquoting. Avoid frequent freeze thaw cycles.


Main REF: Boise, L.H. et al, 1993 CELL 74:5976


Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.

inquire for antibodies to bcl-2, bcl-6


Mouse anti-BCL-Xl Monoclonal ab     (HUMAN/Rat/Mouse)

cat# RDI-BCLXLHabm        $438.00/vial 50ug (0.2ml)

        RDI-BCLXLHabm-1    $750.00/vial 150ug (0.6ml)

Background: BCL-x is related to the BCL-2 protein and can function independently of BCL-2 in regulating apoptosis. the bcl-x transcript is expressed in a number of tissues, with the highest levels seen in the lymphoid and central nervous systems. Two distinct cDNA species, bcl-xl and bcl-xs, have been observed and appear to arise from alternate 5' splice sites located within the first coding exon of bcl-x gene. BCL-xl is composed of 233 amino acids and is similar in size and structure to bcl-2. The bcl-xs polypeptide shows a deletion of 63 amino acids which consist of the region of bcl-xl with the highest degree of amino acid identity to bcl-2. Like bcl-2, bcl-xl is capable of inhibiting cell death upon growth factor withdrawal when it is transfected into an IL-3 dependent cell line. However, the bcl-xs gene product inhibits the ability of bcl-2 to enhance cell survival in the absence of growth factors.

isotype: mIgG1

package: 50ug or 150ug purified IgG1 at 0.25mg/ml in 50% glycerol, 20mM sodium phosphate pH 7.5, 150mM NaCl, 1.5mM NaN3, 1mg/ml BSA

antigen: a fragment corresponding to amino acids 18-233 of rat bcl-Xl protein

USe: Suitable for western blot on human, rat and mouse using approx 0.5-1 ug/ml ab on total cell lysate of human endothelial cells. Major band at Mw 26kDa.

-immunohistochemistry & immunofluorescence (Jurkat fixed cells).

Storage: Store at -20 DEG C upon receipt. Avoid frequent freeze thaw cycles. Recommend aliquoting. Avoid frequent freeze thaw cycles.

Main REF: Boise, L.H. et al, 1993 CELL 74:5976

Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics.  It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.



RDI Division of Fitzgerald Industries Intl

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (800) 370-2222

      or (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com

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