rev:   November 3, 2003

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  ANTIBODIES  

                                                      (anti-Human and others as indicated)
RDI Division of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.


Mouse anti-Beta Arrestin 1 Monoclonal ab

cat# RDI-BARREST1abm      $438.00/vial 50ug

       RDI-BARREST1abm-1   $750.00/vial 150ug

Background: B arrestins were discovered by their ability to modulate the interactions between the phosphorylated B2-Adrenergic receptors and G proteins. This modulation resulted in a diminished B2-adrenergic receptor function, also known as desensitization. Because arrestins are found at the synaptic terminals, they may provide a termination mechanism that allows the neurons to regain their original polarization and respond to a new neurotransmitter stimulus. The C-terminal region of arrestins is involved in selecting the phosphorylated and activated adrenergic receptors. The B-arrestin 1 gene encodes for a protein of 418 amino acids with an approx molecular weight of 55kDa. B-arrestin 1 is highly homologous to the 45kDa B-arrestin 2. Both proteins are widely expressed, but are especially abundant in the central nervous system.

isotype: mIgG1

package: 50ug (200ul) or 150ug (600ul) (at 0.25mg/ml in 50% glycerol, PBS + 1.5mM NaN3 & 1mg/ml BSA)

antigen: a protein fragment from aa 262-409 C term region rat B-arrestin 1

Use: Suitable for western blot on human, rat and mouse under using approx 1ug/ml ab on total cell lysate of mouse macrophages treated with IFN-G and LPS. Major band =Mw 55 kDa.

Storage: Store at -20 DEG C upon receipt. . Recommend aliquoting. Avoid frequent warming cycles.


Main REF: -Attramadal, H. et al. 1992 J. Biol. Chem 267:17882- 17890

                 -Gurevich, V.V. et al. 1995 J. Biol. Chem. 270:720-731

-copyright by owner

Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.


see also cell lysates
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RDI Division of Fitzgerald Industries Intl

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

EMAIL:antibodies@fitzgerald-fii.com

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