rev:       May 5, 2005

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  ANTIBODIES  

(anti-Human and others as indicated)

RDI Division of Fitzgerald Industries Intl  offers a wide line of  antibodies. Since no one antibody works best for all applications (neutralization, blotting, ELISA, etc), we offer many different types of antibodies to help solve this problem. Please inquire for other applications or types of antibodies not listed below.


Anti-URP1 Polyclonal Antibody

Catalog Number: RDI-ALS24360         $312.00/100ug

                            RDI-ALS24360X       $1875.00/1mg

Lot Number:

Quantity: 100ugg in 100ul (1 mg/ml) in PBS containing 0.02% sodium azide.

Description: Due to a concerted effort to identify biomarkers for lung and colon carcinomas by genome-wide transcriptional profiling, the identification and cloning of one such gene as well as two additional closely related genes was achieved. Due to the strong sequence homology to the C. elegans UNC-112 a novel gene gene was named URP1, for UNC-112 related protein. Another novel related gene, URP2 and the previously discovered MIG-2 gene was also identified. Transcriptional analysis shows that only URP1 is significantly differentially regulated, being over-expressed in 70% of the colon carcinomas and 60% of the lung carcinomas tested. Quantification of URP1 expression by qRT-PCR showed up-regulation of the gene by 60-fold in lung tumors and up to nearly 6-fold in colon tumors. Northern blot analysis of URP1 indicates that normal expression is restricted to neuromuscular tissues. In contrast, the expression of URP2 appears to be confined primarily to tissues of the immune system. URP1 has the potential to be one of the most important prognostic and diagnostic markers of colon or lung cancer.

Host Species: Rabbit

Specificity: Reacts with residues 643-660 (VHEYIGGYIFLSTRSKDQ) of the 77 kDa human URP1 protein. Sequence is 100% conserved between almost all species (mouse, rat, canine, bovine, chimpanzee, Xenopus).

Applications: Western blot - Use at 1:1,000 dilution. However, the investigator should determine the optimal dilution for a specific application such as immunohistochemistry.

    Western blot: positive control human lung adenocarcinoma cell line NCI-H322 lysate. Band approx 77kda

Format: Affinity purified IgG

Storage: Maintain at +2-8°C for 3 months or at -20°C for longer periods. Stable for 1 year. Avoid repeated freeze-thaw cycles.

Reference: Weinstein E.J. et al. Biochim Biophys Acta. 2003 Apr 17;1637(3):207-16.

For In Vitro research use only-not for use in or on humans or animal-not for use in diagnostics


RDI Div of Fitzgerald Industries Intl

(Research Diagnostics Inc)

34 Junction Square Drive

Concord MA 01742-3049

USA

phone (978) 371-6446 or (800) 370-2222

fax     (978) 371-2266

email: sales@researchd.com

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