rev:   October 19, 2004

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Human Cytokine/Growth Factor/Chemokines Sample Spec sheets (subject to change without notice):


DATA SHEET:  recombinant Human INTERLEUKIN-17B (IL-17B)

-IL-17B is a disulfide-linked homodimer of two 161 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17B is expressed by T-cells and has been shown to stimulate release of TNF-alpha and IL-1beta from cells of the monocyte lineage. This recombinant human IL-17B is a 36.6 kDa disulfide-linked homodimer of two 161 amino acid polypeptide chains.

Catalog#: RDI-2028

Package Size: 10 micrograms $231.00   $219.00/package 2 or more

                       Mini-Pack: cat#RDI-2028p $94.000/2ug            -inquire for custom sizes/bulk packaging

Supplied: sterile filtered solution is lyophilized from PBS with no additives.

Source: E. Coli

Purity: >98% by SDS-Page and HPLC analysis. Endotoxin level is less than 0.1ng per ug (1EU/ug) of IL- 17B.

Reconstitution: Lyophilized IL-17B should be reconstituted in sterile DI water to a concentration of 0.1-1mg/ml. Allow to set at least 30 minutes, rotate or vortex mix. Centrifuge for 1-2 minutes at 1000rpm to concentrate solution in bottom of vial. This solution can be diluted into other buffered solutions or stored at 4 DEG C for up to 1 week or at -20 DEG C for future use. It is recommended that a carrier protein (0.1% BSA or HSA)or medium serum be added to diluted material.

Storage: The lyophilized powder is stable at room temperature for a few weeks but it is best stored desiccated at -20 DEG C. Reconstituted IL-17B should be stored in working aliquots at -20 DEG C. AVOID FREQUENT FREEZE THAW CYCLES.

Reactivity: Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10ng-100ng. Please Note: Results may vary with PBMC donors.

AA Sequence:

MQPRSPKSKR KGQGRPGPLA PGPHQVPLDL VSRMKPYARM

EEYERNIEEM VAQLRNSSEL AQRKCEVNLQ LWMSNKRSLS

PWGYSINHDP SRIPVDLPEA RCLCLGCVNP FTMQEDRSMV

SVPVFSQVPV RRRLCPPPPR TGPCRQRAVM ETIAVGCTCI F

Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics.  It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.


see also recombinant human IL-17F  & recombinant IL-17A & RDI-IL17-E & IL-17A

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