rev:    October 19, 2004

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Human Cytokine/Growth Factor/Chemokines Sample Spec sheets (subject to change without notice):


DATA SHEET:  recombinant Human INTERLEUKIN-17D (IL-17D)

-The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 155 amino acid chains, secreted by activated T-cells and acts on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region and differ from one another in their N-terminal segments and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as disulfide-linked homodimers. IL-17D has the ability to stimulate the production of IL-6, IL-8 and GM-CSF and inhibits hemopoiesis of myeloid progenitor cells in colony forming assays. This Recombinant IL-17D is a disulfide-linked homodimer with a total weight of 40.5 kDa, consisting of 370 amino acid residues.

Catalog#: RDI-2027

Package Size: 10 micrograms $231.00    $219.00/package 2 or more

             -inquire for custom sizes/bulk packaging                   

Supplied: sterile filtered solution is lyophilized from PBS with no additives.

Source: E. Coli

Purity: >98% by SDS-Page and HPLC analysis. Endotoxin level is less than 0.1ng per ug (1EU/ug) of IL- 17D.

Reconstitution: Lyophilized IL-17D should be reconstituted in sterile DI water to a concentration of 0.1-1mg/ml. Allow to set at least 30 minutes, rotate or vortex mix. Centrifuge for 1-2 minutes at 1000rpm to concentrate solution in bottom of vial. This solution can be diluted into other buffered solutions or stored at 4 DEG C for up to 1 week or at -20 DEG C for future use. It is recommended that a carrier protein (0.1% BSA or HSA)or medium serum be added to diluted material.

Storage: The lyophilized powder is stable at room temperature for a few weeks but it is best stored desiccated at -20 DEG C. Reconstituted IL-17D should be stored in working aliquots at -20 DEG C. AVOID FREQUENT FREEZE THAW CYCLES.

Reactivity: in testing

AA Sequence:

APRAGRRPAR PRGCADRPEE LLEQLYGRLA AGVLSAFHHT

LQLGPREQAR NASCPAGGRP ADRRFRPPTN LRSVSPWAYR

ISYDPARYPR YLPEAYCLCR GCLTGLFGEE DVRFRSAPVY

MPTVVLRRTP ACAGGRSVYT EAYVTIPVGC TCVPEPEKDA

DSINSSIDKQ GAKLLLGPND APAGP

Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics.  It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product.


see also recombinant human IL-17F  & recombinant IL-17A & RDI-IL17-E

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