rev:     November 24, 2004

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Human Cytokine/Growth Factor/Chemokines Sample Spec sheets (subject to change without notice):


DATA SHEET:  recombinant Human INTERLEUKIN-17E (IL-17E)

-Interleukin 17 (IL-17/IL-17A) is the founding member of the newly emerging family of proteins, termed the IL-17 family. This family consists of IL-17/IL17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F that share a conserved C-terminal region but different N-terminal segments. These homologous proteins are secreted as a disulfide-linked homodimers but have significantly different biological roles. At low levels IL-17E can be found in several tissues including the brain, kidney, lung, prostate, testis, spinal cord and trachea. IL-17E has been shown to stimulate IL-8 and induces activation of NF-kB. This recombinant IL-17E is a homodimeric protein with a total weight of 33.8kDa containing two 146 amino acid residue chains.

Catalog#: RDI-2025

Package Size: 25 micrograms $231.00    $219.00/package 2 or more

                      Mini-Pack: cat#RDI-2025p $94.000/2ug

                      -inquire for custom sizes/bulk packaging

Supplied: sterile filtered solution is lyophilized from 10mM Acetic Acid with no additives.

Source: E. Coli

Purity: >98% by SDS-Page and HPLC analysis. Endotoxin level is less than 0.1ng per ug (1EU/ug) of IL- 17E.

Reconstitution: Lyophilized IL-17E should be reconstituted in 10mM Acetic acid to a concentration of 0.1-1mg/ml. Allow to set at least 30 minutes, rotate or vortex mix. Centrifuge for 1-2 minutes at 1000rpm to concentrate solution in bottom of vial. This solution can be diluted into other buffered solutions or stored at 4 DEG C for up to 1 week or at -20 DEG C for future use. It is recommended that a carrier protein (0.1% BSA or HSA)or medium serum be added to diluted material.

Storage: The lyophilized powder is stable at room temperature for a few weeks but it is best stored desiccated at -20 DEG C. Reconstituted IL-17E should be stored in working aliquots at -20 DEG C. AVOID FREQUENT FREEZE THAW CYCLES.

Reactivity: Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10ng-100ng (will vary depending on PBMC donors).

AA Sequence:

MYSHWPSCCP SKGQDTSEEL LRWSTVPVPP

LEPARPNRHP ESCRASEDGP LNSRAISPWR

YELDRDLNRL PQDLYHARCL CPHCVSLQTG

SHMDPRGNSE LLYHNQTVFY RRPCHGEKGT

HKGYCLERRL YRVSLACVCV RPRVMG

MW:16873 146 residues

Precautions: For In vitro research Use Only. Not for use in   or on humans or animals or for diagnostics.  It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent fringements that might result with the use of or derivation of this product.


see also recombinant human IL-17F

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