rev:   January 11, 2005

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Human Cytokine/Growth Factor/Chemokines Sample Spec sheets (subject to change without notice):


DATA SHEET:   recombinant HUMAN INTERLEUKIN-19

-IL-19 belongs to the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. Preliminary data suggests that IL-19 is a proinflammatory cytokine because it up-regulates IL-6 and TNF-alpha and induces apoptosis through TNF-alpha. IL-19 signals through the type I IL-20R. Human and murine IL-19 share 71% amino acid sequence identity. Recombinant human IL-19 is a 17.9 kDa protein containing 153 amino acid residues. In solution IL-19 exists predominantly as a non-disulfide-linked dimer.

Catalog#: RDI-2019

Package Size: 10 micrograms $231.00    $219.00/package 2+

                         MINI-PACK:cat#RDI-2019P   $94.00/2ug
                         -inquire for custom sizes/bulk packaging

Supplied: Lyophilized powder from 10mM NaCitrate pH5.0.

Source: E. Coli

Purity: >98% by SDS-Page analysis and HPLC analysis. Endotoxin level less than 0.1ng/ug (1EU/ug)

Reconstitution: We recommend a quick spin followed by reconstitution in 10mM NaCitrate pH 3.0 to a concentration of 0.1-1.0 mg/ml. Allow to set at least 30 minutes at 4 DEG C, tighten cap and rotate to reconstitute any material on sides of vial. If desired, you can centrifuge at 1000 rpm for 1 minute to concentrate volume in bottom of vial. This solution can be diluted into other buffered solutions contiaing carrier protein or medium containing serum and stored at 4 DEG C (up to 1 week) or -20 DEG C long term)

Storage: The lyophilized powder is stable at room temperature for a few weeks but it is best stored desiccated at -20 Deg C. Reconstituted IL-19 should be stored in working aliquots at -20DEG C and used within 2-3 months. AVOID FREQUENT FREEZE THAW CYCLES.

Reactivity: Recombinant Human IL-19 activates STAT following receptor ligand interaction

AA Sequence:

MLRRCLISTD MHHIEESFQE IKRAIQAKDT FPNVTILSTL ETLQIIKPLD

VCCVTKNLLA FYVDRVFKDH QEPNPKILRK ISSIANSFLY MQKTLRQCQE

QRQCHCRQEA TNATRVIHDN YDQLEVHAAA IKSLGELDVF LAWINKNHEV MSSA

Precautions: For In vitro research Use Only. Not for use in or on humans or animals or for diagnostics.  It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. We are not responsible for any patent infringements that might result with the use of or derivation of this product


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